In the fifth edition, WHO classifies pediatric tumors separately from adult tumors.
Myeloid neoplasms
Myeloproliferative neoplasms
- Chronic myeloid leukemia, BCR::ABL1 positive
Myelodysplastic/myeloproliferative neoplasms
- Juvenile myelomonocytic leukemia
Myelodysplastic syndromes
- Refractory cytopenia of childhood
- Myelodysplastic syndromes with excess blasts
Myeloid neoplasms with germline predisposition
Myeloid proliferations associated with Down syndrome
Acute myeloid leukemia and related neoplasms
- Acute myeloid leukemia, NOS
- Acute myeloid leukemia with recurrent genetic abnormalities
Mast cell neoplasia
- Mastocytosis
Lymphoid neoplasms
Precursor lymphoid neoplasms
- B-cell lymphoblastic leukemia/lymphoma
- T-cell and natural killer cell lymphoblastic leukemia/lymphoma
- T-lymphoblastic leukemia/lymphoma
- Early T-cell precursor lymphoblastic leukemia
- NK-lymphoblastic leukemia/lymphoma
Mature B-cell neoplasms
- Primary mediastinal (thymic) large B-cell lymphoma
- Diffuse large B-cell lymphoma, NOS
- EBV-positive diffuse large B-cell lymphoma, NOS
- Large B-cell lymphoma with IRF4 rearrangement
- Pediatric-type follicular lymphoma
- Pediatric nodal marginal zone lymphoma
- ALK-positive large B-cell lymphoma
- Lymphomatoid granulomatosis
- Plasmablastic lymphoma
- Grey-zone lymphoma
- Burkitt lymphoma
- Burkitt like lymphoma with 11q aberration
Mature T/NK-cell neoplasms
- Peripheral T-cell lymphoma
- Aggressive NK-cell leukemia
- Mycosis fungoides
- Anaplastic large cell lymphoma, ALK positive
- Hepatosplenic T-cell lymphoma
- Primary cutaneous CD 30 + T-cell lymphoproliferative disorders
- Systemic EBV + T cell lymphoma of childhood
- Hydroa vacciniforme lymphoproliferative disorder
- Subcutaneous panniculitis like T cell lymphoma
Hodgkin lymphoma
- Classical Hodgkin lymphoma
- Nodular lymphocyte predominant Hodgkin lymphoma
Histiocytic and dendritic cell neoplasms
- Langerhans cell histiocytosis and other histiocytic/dendritic cell neoplasms
Immunodeficiency associated lymphoproliferative disorders
- Primary immunodeficiency associated lymphoproliferative disorders
- Post-transplant lymphoproliferative disorders
- HIV-associated lymphoproliferative disorders