Bickerstaff encephalitis

  • Rare acute syndrome
  • Subgroup of ADEM
  • Subtype of anti-GQ1b IgG antibody syndrome
  • Inflammation confined to brainstem
  • Preceded by febrile illness
  • Benign prognosis
  • Ataxia, ocular paresis, impaired reflexes
  • Pathogenesis uncertain
  • No CSF oligoclonal bands
Imaging
  • Extensive high T2 signal in midbrain and pons, sometimes in basal ganglia and thalamus
  • Lesions resolve with time, good prognosis
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Mondéjar, R., J. Santos, and E. Villalba. “MRI findings in a remitting-relapsing case of Bickerstaff encephalitis.” Neuroradiology 44.5 (2002): 411-414.

Hagenkötter, B., J. Forster, and A. Ferbert. “Bickerstaff encephalitis. Clinical and magnetic resonance follow-up studies.” Der Nervenarzt 69.10 (1998): 892-895.