- Affinity of carbon monoxide for Hb is 250 times for than oxygen
- Carboxyhemoglobin reduces oxygen carrying capacity of Hb
- Headache, tinnitus, dizziness, nausea
- Survivors have severe extrapyramidal disorder or dementia
- Bilateral globus pallidus necrosis, sometimes involved lenticular nuclei and caudate. Thalami and hippocampi rarely involved. Sometimes distal frontal matter involved
- Bilateral basal ganglia low T1, high T2
- Microbleeds may be seen
- When severe, symmetric involvement of white matter of periventricular region, corpus callosum, internal capsule, subcortical white matter, cerebellar white matter
- Acute phase – DWI restriction in basal ganglia
- Eventually lesions cavitate and atrophy
Horowitz, A. L., R. Kaplan, and G. Sarpel. “Carbon monoxide toxicity: MR imaging in the brain.” Radiology 162.3 (1987): 787-788.
Chang, Kee Hyun, et al. “Delayed encephalopathy after acute carbon monoxide intoxication: MR imaging features and distribution of cerebral white matter lesions.” Radiology 184.1 (1992): 117-122.