Chronic pancreatitis

  • Irreversible inflammation and fibrosis
  • Multiple prior attacks of acute disease
  • Abdominal pain
  • Loss of exocrine and endocrine function
  • Weight loss, steatorrhea, diabetes
  • Diagnosis made when 3 of the following 4 is present
    • Parenchymal calcifications
    • Intraductal calcifications
    • Parenchymal atrophy
    • Cystic lesions
  • Focal pancreatitis and malignancy in chronic pancreatitis are hard to distinguish on imaging. One sign described is the ‘duct penetrating sign’. The main duct traversing inflammation shows a patent lumen, but a malignant fibrotic lesion with obstruct it. Secreting enhanced MRCP opens up inflammatory mass ducts, while cancer mass ducts remain stenosed  
  • Vascular complications are more common in longstanding chronic pancreatitis