Frontotemporal lobar degeneration

• Tau protein or progranulin mutation
• Language and behavioral symptoms
• 5-10% of all dementia
• Autosomal dominant, Chr. 17

Lund-Manchester criteria (3 main subtypes)

• Behavioral variant frontotemporal dementia
• Progressive non-fluent aphasia
• Semantic dementia

Imaging

• Asymmetrical atrophy of frontal and temporal lobes
• Semantic dementia: marked left temporal lobe atrophy (temporal pole > hippocampus)
• Behavioral variant: frontal lobe atrophy is often mild at time of diagnosis

Read more

Möller, Christiane, et al. “Alzheimer disease and behavioral variant frontotemporal dementia: automatic classification based on cortical atrophy for single-subject diagnosis.” Radiology 279.3 (2016): 838-848.

Matsuo, Koushun, et al. “Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography.” Neuroradiology 50.7 (2008): 605-611.