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- Patchy, asymmetrical
- Prefers grey matter
- Herpes: anterior temporal and inferior frontal cortical region
- Limbic encephalitis: herpes involvement of hippocampi and cingulate gyrus
- EBV: patchy enhancement and edema
- Widespread hemispheric involvement: Coxsackie, entero and echo viruses
- Thalamic and upper brain stem involvement, often hemorrhagic: Japanese encephalitis and West Nile virus
- Cerebellitis: ADEM, pertussis, lead poisoning, vasculitis
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